This chapter will review the principles and applications of various corneal imaging techniques for DED, such as Slit-Lamp Biomicroscopy, Fluorescein CorneoGraphy, In Vivo Confocal Microscopy, Optical Coherence Tomography, Lipid Layer Interferometry, Topography, and. This chapter will review the principles and applications of various corneal imaging techniques for DED, such as Slit-Lamp Biomicroscopy, Fluorescein CorneoGraphy, In Vivo Confocal Microscopy, Optical Coherence Tomography, Lipid Layer Interferometry, Topography, and. Many of us may have seen That “one” topography scan that seemed like that of keratoconus but turned out to be regular cornea after instilling a drop of lubricant in the eyes. Many of us would have also ordered for a tomograph to be repeated for a patient in the clinic and then wondered as to how. The TERA Dry Eye Imager is a multimodal platform purpose-built to detect, grade, and manage dry eye disease. Automated to. In early 17th century, Schiener used reflection of marbles from the cornea as perhaps the earliest corneal topography. Placido's disc was a major advancement in the late 19th century. Placido disc has stood the test of time and the current placido based topographers work on the same. Keywords: Corneal topography, Repeatability, Pentacam, Severe dry eye disease Accurate repeated measurements of an ophthalmic device are crucial to obtain a reliable data in ophthalmology practice.